Researchers found that daily orange juice alters thousands of immune-cell genes in the human body.
Many affected genes regulate blood pressure, limit inflammation, and control sugar metabolism, supporting heart health.
Scientists stress that a simple breakfast drink can significantly affect key cardiovascular and metabolic processes.
Daily Intake Reduces Inflammation and Improves Regulation
Adults drank 500 ml of pasteurised orange juice daily for two months in recent studies.
After 60 days, inflammation-related genes such as NAMPT, IL6, IL1B, and NLRP3 became less active.
The SGK1 gene, which controls kidney sodium retention, also showed reduced activity, lowering blood pressure.
Researchers say orange juice relaxes blood vessels, eases inflammation, and protects the heart.
The flavonoid hesperidin contributes antioxidant and anti-inflammatory effects and influences cholesterol and sugar metabolism.
Body type affects responses: overweight participants showed stronger fat-metabolism changes, while leaner participants had bigger inflammation-gene shifts.
Juice Supports Metabolic and Cardiovascular Health
Analysis of 15 controlled studies with 639 participants found that orange juice reduces insulin resistance and LDL cholesterol.
Overweight adults who drank juice daily showed slightly lower systolic blood pressure and higher HDL cholesterol.
Metabolite studies show juice improves energy use, cell signalling, and inflammatory pathways.
One-month consumption increased gut bacteria that produce short-chain fatty acids, aiding blood pressure and reducing inflammation.
In people with metabolic syndrome, orange juice improved endothelial function, helping vessels relax and lowering heart-attack risk.
Other studies confirm juice generally reduces inflammation, promotes blood flow, and improves heart-health markers.
Workers at a Brazilian orange juice factory displayed lower apo-B levels, reducing heart-attack risk.
