Researchers at the University of East Anglia say they’ve developed the first reliable blood test for myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS).
Currently, ME/CFS is diagnosed only through symptoms, often leaving patients undiagnosed or misdiagnosed for years.
“This could transform how we diagnose and manage the disease,” said lead researcher Prof Dmitry Pshezhetskiy.
The study, conducted with Oxford Biodynamics, found unique DNA-folding patterns in ME/CFS patients that distinguished them from healthy individuals.
Testing 108 participants, scientists reported 92% sensitivity and 98% specificity — suggesting high accuracy.
“This is a significant step forward,” Pshezhetskiy said. “We now have a simple, accurate test to confirm diagnosis.”
Experts welcomed the breakthrough but urged caution. “It must be validated in larger, independent studies,” said Dr Charles Shepherd of the ME Association.
Prof Chris Ponting called the claims “premature,” noting the test could cost around £1,000 and needs further verification.

